Define Glutamine and its Benefits

An amino acid (a building block of protein), which is found naturally in the body is called glutamine.


Glutamine powder is used to better nutrition, bone marrow transplant, recovery from surgery, burns, sickle cell disease, radiation, injuries, complications of HIV/AIDS, chemotherapy, and many other disease treatments. For speedy recovery after surgery and other conditions, it is given intravenously.

It is available on the market in capsule and powdered form. Endari (Emmaus Medical, Inc) and NutreStore (Emmaus Medical, Inc) are U.S. Food and Drug Administration (FDA) prescripted glutamine products. Commercially it produced by the fermentation process.

How does glutamine work?

It is found in the body as an abundant free form of amino acid. Amino acids are basically made up of proteins. Moreover, it produces in the muscles and then distributes to the organs through the blood where needed. 

It is necessary for the body to make other chemicals such as glucose and other amino acids. They provide fuel (nitrogen and carbon) to many other body cells. It helps in gut function, the immune system, and other important processes in the body, especially in stress.

After surgery or traumatic injury, nitrogen is important to heal the wounds and keeps the fundamental organs functioning. From glutamine powder, almost one-third of this nitrogen comes.

If the body consumes more glutamine than the muscle can produce (i.e., at times of stress and anxiety), the muscle may be damaged. This can happen in people with HIV/AIDS.

Chemotherapy of some types can lower its levels in the body. 

To prevent chemotherapy-related damage the glutamine treatment is used to maintain the affected tissue life.

What’s the use of glutamine?

Likely Effective for

  • Sickle cell disease: It is an FDA-accepted prescription drug for sickle cell disease. By taking it orally twice daily lowers the sudden complications of sickle cell disease. Prescripted glutamine might also lower the number of times people are in the hospital and the number of days in the hospital for a crisis.

Possibly Effective for

  • Burns: Administering glutamine reduces the chance of death in people with severe burns and also lowers the risk of severe infection through a feeding tube. Administering glutamine intravenously (by IV) reduces the risk of infections of major burn in people. But that does not decrease the risk of death.
  • Critical illness (trauma): While there are some conflicting findings, most research shows that after major injuries, it prevents bacteria from coming out of the intestine and affecting other parts of the body. It might also lower the chance of hospital-acquired infections in people who are critically ill. When administered intravenously instead of a feeding tube, it reduces hospital-acquired infections. It does not decrease the risk of death in critically ill people.
  • People with HIV/AIDS lose weight. Getting it orally may help to absorb food and gain weight in HIV/AIDS patients. 40 grams per daily dose gives the best results.
  • Improvement after the surgery. It decreases the days spent in hospitals when given to the patient by IV with intravenous nutrition, especially in abdominal operations. It eliminates the hospital’s infections after serious surgeries. It eliminates the risk of infection and increases the recovery after a bone marrow transplant when giving to the patient. by Iv along with intravenous nutrition. All bone marrow transplant patients not getting the same results and improvement. After any type of surgery, it does not decrease the risk of death.


  • Athletic efficiency. Orally taking glutamine does not get good results to athletic efficiency.
  • Inflammatory bowel disease (Crohn’s disease). Orally taking glutamine does not better the symptoms of bowel disease.
  • Kidney or bladder stones (cystinuria) are Inherited diseases. Orally taking glutamine does not improve the kidney and bladder stone.
  • Infants less weight than 2500 grams (5 pounds, 8 ounces). glutamine given to infants with low weight at birth does not improve feeding. It doesn’t increase the growth rate. Giving it at the first 30 days of life to infants of less weight does not improve the behavior of school age, thinking skills, motor skills.
  • Inherited disorders group that creates muscle loss (muscular dystrophy) and muscle weakness. Research shows that orally taking it in muscular dystrophy infants does not develop muscle strength.
  • Premature Infant’s development and growth. It does not better the growth nor prevents the illness and not early death in premature infants.
  • Radiation therapy causes diarrhea. Research shows that orally taking it does not eliminate diarrhea or does not lower the hardness of diarrhea in people with pelvic cancer caused by radiation.

Glutamine Benefits For Health

In our bodies, glutamine is the most sufficient amino acid. It helps to develop many health functions, In which:

  • Manufacturing protein for muscle tissue.
  • Fueling cells that save our intestines
  • Helps the immune system cells
  • Support to detox the other substances from the liver

Our bodies manufacture it, but also consume food like corn, milk, wheat, and peanuts. Lack is too rare and not origin by insufficient intake from a genetic disorder.

However, research suggests that supplements with glutamine offer some health advantages, and scientists proceed to research the amino acid’s strength to stop or deal with definite states.

Health advantages

When our body manufactures the glutamine, it is required to use, it may need more when under pressure from a wound or sickness.

Many clinical works revealed that glutamine assists to reduce the results of cancer treatments, like oral inflammation, nausea, muscle wasting, diarrhea, and vomiting. Supplementation is also associated with small hospital stays and decreased death rates for sick patients.

These findings are helpful to research into the health effects of the glutamine, consisting of:

Immune System Support

Glutamine is the foremost source of fuel for the lymphocytes of your body, white blood cells, which fight disease and infection. But when we get sick or injured, the level of glutamine in our blood drops, which reduces the ability of immune cells to defend our body.

Although there exists differing evidence as to whether it increases immunity in healthy people, studies have shown that it can improve recovery times and decrease problems when ill.

Intestinal Health Regulation

Glutamine is closely linked to the activity of the immune system in our gut. Amino acids are helpful to maintain our intestinal lining, which makes sure that our body absorbs the required nutrients. The amino acids also help to have good health and preventing serious issues such as leaky gut syndrome.

The largest organ in our immune system is the gut, it is the reason several scientists consider that glutamine is helpful for better immunity.

Evidence also exists that glutamine supplements can also benefit people with intestinal conditions, such as celiac disease, gut inflammation, and Crohn’s disease.

Supporting Muscle Recovery

Glutamine is quite essential for maintaining muscle protein. Initially, it gained popularity as a fitness supplement for fat burning and muscle gain. The scientists are continuously studying such claims, and if the study does not confirm the effects of muscle growth, it can improve exercise recovery and decrease fatigue.

Studies show that when glutamine is supplemented, athletes experience muscle pain and loss of strength. It can also reduce muscle damage and exercise performance, but research into these effects is still ongoing.

Health Risks

Glutamine is considered harmless in normal amounts because our bodies make glutamine and it can be found in several foods. But a few potential health risks also exist, so you have to discuss with your doctor before taking glutamine supplements in your diet.

Possible risks to consider before taking glutamine may consist of:

Long-Term Supplementation

Over time, a large amount can change how the human body uses and distributes the amino acids consisting of glutamine itself. We don’t know the long-term effect of this change, it can increase the health problem risks.

Dangerous Side Effects

While unusual, its high dose may cause several side effects that need medical attention, consisting of skin color changes, blood in urine, fast heartbeat, rash, or lower back pain, etc.

Mild Side Effects

Introduce a glutamine supplement into your diet can cause several mild effects. The most typical side effects consist of changes in bowel movements and cough.

You have to start with a low dose to adjust your body to the supplement, but if the discomfort is severe or does not go away, talk to your doctor as you may have an allergy.


There does not exist any evidence for the confirmation that glutamine is safe and secure for breastfeeding or pregnant women.

Kidney and Liver diseases

In people with these conditions, glutamine supplements can worsen the symptoms of kidney disease and the liver.

Quantity and Dosage

Its frequency and amount you are taking depending upon the cause you are going to take it. Typically, scientists use 5 to 45 grams every day for six weeks without any side effects for the clinical trials.

According to the researcher’s estimation, we take 3 to 6 grams a day in the diet. As we don’t know the long-term effects of intaking high glutamine, add small amounts to your diet as recommended in the product instructions. But first of all, you have to talk with medical experts to ensure it is good for your health.

Also Read; Meal Plan to Get Ripped in 4 Weeks

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